Does Acid/Base Balance Really Matter?

Dear Dr. Cordain,Q -

I recently read an article pertaining to Acid/Alkaline balance of foods. It said you should not believe that it matters whether foods are acidic or alkaline, because no foods change the acidity of anything in your body except your urine. Your stomach is so acidic that no food can change its acidity, and foods (citrus fruits, vinegar, and vitamins such as ascorbic acid or folic acid) do not change the acidity of your stomach or your bloodstream. So does it really matter? Thank you, Mike HooverNovi, MIA - Thank you for your question Mike. It is a common misunderstanding that because the food you eat does not change the pH of your blood or stomach acid, it is inconsequential to your health.Bone mineral content is based upon net calcium balance. This is the amount of calcium you take in minus the amount of calcium you excrete. This helps explain why the U.S. has one of the highest rates of osteoporosis in the world despite having one of the highest calcium intakes worldwide.All digested food ultimately reports to the kidneys as either acid or base. If the diet yields a net acid load, the acid must be buffered by the alkaline stores of base in the body. The highest acid-producing foods are hard cheeses, cereal grains, salted foods, meats, fish and eggs. The only alkaline, base-producing foods are fruits and vegetables. Because the average American diet is overloaded with grains, cheeses, salted processed foods, and fatty meats at the expense of fruits and vegetables, virtually everyone in the U.S. has chronic low-grade metabolic acidosis.Many nutritionists think the degree of this metabolic acidosis is mild and inconsequential since it does not affect blood pH. However, this perturbation of systemic acid-base balance is, in part, responsible for the age-related loss of bone and skeletal muscle mass. To buffer the excess acid, alkaline calcium salts are released from bone. Glutamine is released from the muscles and utilized for the generation and excretion of ammonium, gradually leading to sarcopenia.Many studies with kidney patients have shown that a chronic metabolic acidosis leads to bone loss1 and muscle loss2. For most folks, the dietary-induced damage to the skeleton, skeletal muscle, and kidneys is cumulative over a lifetime and appears later in life. Studies by Dr. Anthony Sebastian's team have shown that when healthy people were given potassium bicarbonate (a base) in order to reverse metabolic acidosis, it improved biomarkers of bone health3 and reduced muscle loss4. Likewise in 2006, an intervention study found that fruits and vegetables (as opposed to grains) improved bone health5.Among Eskimos, age related bone loss starts earlier in life and is more pronounced than it is among Westerners due to the combination of an almost exclusively animal diet and very low calcium intake in the Eskimo diet.It's also important to mention that some studies have shown that hypertension could also result from a disturbance in the acid-base balance. Further evidence of this link comes from the fact that chloride seems to be a major determinant of the diet's net acid load6, and from the fact that old studies show that chloride raised blood pressure to a significantly higher level than did sodium7.Normal adult humans eating the typical Western diet, whose metabolism yields more acids (sulphuric acid from meat, fish, eggs, dairy and cereal grains) than base (bicarbonate from fruits and vegetables), have chronic, low-grade metabolic acidosis. This is aggravated by the normal age-related decline in overall renal function.To correct this low-grade metabolic acidosis, focus on eating a high amount of fruits and vegetables, and lower consumption of grains, hard cheese, and chloride. This will bring the body back into acid/base balance, which naturally brings it back into calcium balance, and has numerous other health benefits. Remember, the goal is to avoid a net acid load on your kidneys.

References are available at www.ThePaleoDiet.com/v4n13.shtml.

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Red Yeast Extract Reduces Major Coronary Events in Large, Randomized Clinical Trial

Red Yeast Extract Reduces Major Coronary Events in Large, Randomized Clinical Trial

News Author: Michael O'RiordanCME Author: Charles Vega, MD

From Heartwire — a professional news service of WebMD

June 16, 2008 — A large, randomized clinical trial with the partially purified extract of Chinese red yeast rice has shown that the extract, known as Xuezhikang (XZK), reduced the risk of major coronary events by almost 50% as well as reduced the risk of cardiovascular and total mortality, in patients with a previous myocardial infarction (MI) [1].
"Results showed that treatment of this study population with XZK produced profound changes in both lipoprotein lipids and the number of recurrent coronary events," writes lead investigator Dr Zongliang Lu (Peking Union Medical College, Beijing, China) in the June 15, 2008 issue of the American Journal of Cardiology. "The decrease in these events found in the present study appears to exceed those reported with statin monotherapy in a similar trial of Western patients enrolled in the Cholesterol and Recurrent Events and other statin trials."
Extracts of red yeast rice have been widely used in China for therapy in patients with circulatory and digestive disorders for centuries, and preparations of red yeast rice have been shown to lower plasma lipoprotein levels. Lovastatin, the first statin approved in the United States, occurs naturally in certain forms of red yeast rice that are made when the rice is cultivated with the mold Monascus purpureus. Interestingly, XZK also gives Peking duck and spare ribs their distinctive bright color.
In this study, known as the Chinese Coronary Secondary Prevention Study, investigators sought to determine the long-term efficacy of XZK on the reduction of recurrent cardiovascular events in Chinese patients with average low-density lipoprotein (LDL)-cholesterol levels. The multicenter, randomized, double-blind study was conducted in 4870 patients, aged 18 to 70 years, over a five-year period at more than 60 hospitals in the People's Republic of China. All patients had total-cholesterol levels between 170 and 250 mg/dL and triglyceride levels ≤ 400 mg/dL.
Patients in the treatment arm received 300-mg capsules of XZK. After an average follow-up of 4.5 years, the primary end point, a composite of nonfatal MI and death from coronary heart disease, was 10.4% in the placebo group and 5.7% in the XZK-treated group, a relative risk reduction of 45%. Treatment with XZK also decreased cardiovascular and total mortality, reduced the need for revascularization, and significantly lowered total- and LDL-cholesterol levels. Cancer risk was also significantly reduced with the red yeast extract.
Changes in plasma lipids in patients treated with XZK for 3.5 years
Lipid measures (mg/dL)
XZK, baseline
XZK, on therapy
p
Total cholesterol
207
180
< 0.001
LDL cholesterol
129
103
< 0.001
HDL cholesterol
46
48
< 0.001
Non-HDL cholesterol
161
130
< 0.0001
Triglycerides
164
140
< 0.001
Events according to treatment arm
Event
Placebo, n = 2441 (%)
XZK, n = 2429 (%)
Relative risk reduction (95% CI)
Nonfatal MI
4.9
1.9
0.38 (0.27 - 0.54)
Coronary disease mortality
5.5
3.8
0.69 (0.52 - 0.88)
Fatal MI
1.2
0.8
0.67 (0.38 - 1.20)
Fatal stroke
0.5
0.5
0.91 (0.42 - 1.99)
Coronary revascularization
4.2
2.8
0.64 (0.47 - 0.86)
Cardiovascular mortality
6.1
4.3
0.70 (0.54 - 0.89)
Cancer mortality
1.2
0.5
0.44 (0.23 - 0.84)
Total mortality
7.7
5.2
0.67 (0.52 - 0.82)
The authors point out that the XZK capsules contain a combination of lovastatin, lovastatin hydroxyl acid, ergosterol, and other components. They note that while the lovastatin component is quantitatively predominant, it is "unlikely to account solely for the favorable plasma lipid lowering and rather striking cardiovascular benefit found." The issue, they note, deserves further study, and various components of XZK will need to be adequately isolated and analyzed for consistency, stability, and other pharmacologic properties.
"Future use of this product," they conclude, "will depend on the separation, identification, characterization, and development of a carefully formulated preparation of red yeast rice."
Last August, the US Food and Drug Administration (FDA) warned physicians and consumers to steer clear of several cholesterol-lowering supplements that contain what the FDA terms "unauthorized" lovastatin. As previously reported by heartwire, FDA testing revealed that several brands of nonprescription "red yeast rice extract" supplements contained lovastatin, a regulated prescription drug. In the MedWatch safety alert, the FDA told consumers to "avoid using" the products because they "may contain an unauthorized drug that could be harmful to their health." The FDA has also recently turned away Merck's attempt to sell lovastatin over the counter.
The WBL Peking University Biotech Company Ltd sponsored the study. The Chinese National Scientific and Technological Projects, People's Republic of China, supported the study.
Source
Lu Z, Kou W, Du B, et al. Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction. Am J Cardiol. 2008; published online before print June 9

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